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17/09/2015
The findings, published this week in BJOG, are from three studies.
The Norwegian Institute of Public Health looked at the effects of selective serotonin reuptake inhibitors (SRRIs) on the health of the mother, as well as the long-term development of her child.
Involving data from 51,404 children from the Norwegian Mother and Child Cohort Study, the team examined the effects of prenatal exposure to SSRIs on motor skill development in children at the age of three. In this cohort, 159 mothers reported a prolonged use of SSRIs during pregnancy. Researchers discovered that the children of those mother's did have a slight delay in the development of fine and gross motor skills, compared to children unexposed, but said the differences were so small, that no change in clinical practice was warranted.
Marte Handal, lead author of the study from the Norwegian Institute of Public Health, explained: "Effective treatment of depression during pregnancy is essential and these results should not discourage healthcare professionals from prescribing or continuing antidepressant treatment to those who need it."
A second study, which involved a team from Australia looking at data from 49,000 women registered on the Danish National Birth Cohort, focused on the impact of prenatal exposure to SSRIs on behavioural problems in children at the age of seven.
The findings revealed that untreated prenatal depression (231 children) was associated with an increased risk of problem behaviour in the children, hyperactivity, inattention, and peer problems; but the risk was not seen in the 210 children whose mothers took antidepressants, including SSRIs.
The third study found the same team examining the risk of postpartum haemorrhage in mothers taking antidepressants in the final three months of their pregnancy, at the Women's and Children's Hospital in Adelaide, Australia.
Of the 28,000 women without psychiatric illness, or who were not taking antidepressants (1,292), the risk of postpartum haemorrhage was 11%. However, this increased to 16% for women taking antidepressants (558). Risks of severe postpartum haemorrhage and of postpartum anaemia were almost doubled by SSRI use, the study revealed.
Dr Luke Grzeskowiak, lead author of the studies from The University of Adelaide, is quoted as saying: "Consequently, it is possible that the women who took antidepressants late in pregnancy were those with the most severe illness and it is this which is responsible for the increased risk of postpartum haemorrhage and not the antidepressant."
(JP/LM)
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Study Finds No Long-Term Effect Of Antidepressant Use During Pregnancy
A new study has found no link between the use of antidepressants during pregnancy and the long-term neurodevelopmental or behavioural effect on children.The findings, published this week in BJOG, are from three studies.
The Norwegian Institute of Public Health looked at the effects of selective serotonin reuptake inhibitors (SRRIs) on the health of the mother, as well as the long-term development of her child.
Involving data from 51,404 children from the Norwegian Mother and Child Cohort Study, the team examined the effects of prenatal exposure to SSRIs on motor skill development in children at the age of three. In this cohort, 159 mothers reported a prolonged use of SSRIs during pregnancy. Researchers discovered that the children of those mother's did have a slight delay in the development of fine and gross motor skills, compared to children unexposed, but said the differences were so small, that no change in clinical practice was warranted.
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Marte Handal, lead author of the study from the Norwegian Institute of Public Health, explained: "Effective treatment of depression during pregnancy is essential and these results should not discourage healthcare professionals from prescribing or continuing antidepressant treatment to those who need it."
A second study, which involved a team from Australia looking at data from 49,000 women registered on the Danish National Birth Cohort, focused on the impact of prenatal exposure to SSRIs on behavioural problems in children at the age of seven.
The findings revealed that untreated prenatal depression (231 children) was associated with an increased risk of problem behaviour in the children, hyperactivity, inattention, and peer problems; but the risk was not seen in the 210 children whose mothers took antidepressants, including SSRIs.
The third study found the same team examining the risk of postpartum haemorrhage in mothers taking antidepressants in the final three months of their pregnancy, at the Women's and Children's Hospital in Adelaide, Australia.
Of the 28,000 women without psychiatric illness, or who were not taking antidepressants (1,292), the risk of postpartum haemorrhage was 11%. However, this increased to 16% for women taking antidepressants (558). Risks of severe postpartum haemorrhage and of postpartum anaemia were almost doubled by SSRI use, the study revealed.
Dr Luke Grzeskowiak, lead author of the studies from The University of Adelaide, is quoted as saying: "Consequently, it is possible that the women who took antidepressants late in pregnancy were those with the most severe illness and it is this which is responsible for the increased risk of postpartum haemorrhage and not the antidepressant."
(JP/LM)
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