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21/03/2014

Miscarriage Risk Linked To Low IVF Success

Women who produce fewer eggs during IVF treatment have a higher risk of miscarriage, a new study has claimed.

The research, conducted by King's College London and the University of Birmingham, looked at almost 125,000 IVF pregnancies between 1991 and 2008, and found that around 20% of pregnancies in women who produced fewer than four eggs after the ovarian stimulation phase of IVF ended in miscarriage.

The findings indicated that the quality of eggs in these cases was poorer and those behind the study said the information could be used to improve counselling for couples going through IVF. In addition to the above, the miscarriage rate fell to 15.5% for women who produced between four and nine eggs and 13.8% for those women with between 10 and 14 eggs.

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The average risk of miscarriage across the population is 15%.

IVF treatment involves the stimulation of a woman's ovarian cycle by extracting eggs from their ovaries, fertilising them with sperm in a laboratory, then transferring the embryo into the womb to develop.

Co-author of the study, Dr Sesh Sunkara from the Reproduction Unit at King's College London, said: "I think the information will empower women.

"IVF treatment can be a distressing experience, and miscarrying makes it even more agonising."

Professor Arri Coomarasamy, from the School of Clinical and Experimental Medicine at the University of Birmingham, added: "It has always been a question to be answered, whether women with low ovarian reserve had high miscarriage risk.

"Our study which is the largest to date has shown that women with low ovarian reserve indeed have a high risk of miscarriage. Even younger women with a low ovarian reserve have a high chance of miscarriage."

(JP/MH)

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"Women who produce fewer eggs during IVF treatment have a higher risk of miscarriage, a new study has claimed."